Furfuryl Alcohol → Methanesulfonic acid furan-2-ylmethyl ester

HRID 1693639ノート

反応式

HRID 1693639 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][OH:7].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>C(Cl)Cl>[CH3:15][S:16]([O:7][CH2:6][C:2]1[O:1][CH:5]=[CH:4][CH:3]=1)(=[O:18])=[O:17]

参加物

5

反応物 3

HCID 7361Furfuryl AlcoholHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

生成物 1

HCID 15031413Methanesulfonic acid furan-2-ylmethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To the solution of furan-2-ylmethanol (500 mg, 5.1 mmol) in CH2Cl2 (10 mL) and triethylamine (1.54 g, 15.3 mmol) at 0° C. was added dropwise methanesulfonyl chloride (695 mg, 6.1 mmol). The mixture was stirred at 0° C. for 15 min and was quenched with 10 mL of water. The layers were separated and the aqueous layer was extracted with CH2Cl2 (1×10 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound.

後処理

  1. customwas quenched with 10 mL of water
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with CH2Cl2 (1×10 mL)
  4. dry with materialThe combined organic extracts were dried over anhydrous Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e49580dd74364160a354a59d3be2d06e
出典データセット
uspto-grants-2012_04
特許番号
US08158663B2

反応ノート

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