Phosphorus oxychloride → 5-Bromo-4-chloro-1H-pyrrolo(2,3-b)pyridine
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[CH:11]=[CH:10][NH:9][C:5]2=[N+:6]([O-])[CH:7]=1.P(Cl)(Cl)([Cl:14])=O>CN1C(=O)CCC1>[Br:1][C:2]1[C:3]([Cl:14])=[C:4]2[CH:11]=[CH:10][NH:9][C:5]2=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- -20 °C
実験手順
5-Bromo-1H-pyrrolo[2,3-b]pyridine 7-oxide (19.18 g, 90 mmol) were suspended in 200 mL NMP and cooled to −20° C. Phosphorus oxychloride (41 mL, 450 mmol) was added dropwise over 30 min. The mixture was allowed to warm to 23° C. over 1 h after which it was cooled on an ice bath and quenched with water (800 mL). The solids were filtered and recrystallized from ethyl acetate and hexanes to give 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine (10 g, 48%). 1H NMR (500 MHz, DMSO-d6) δ 12.25 (bs, 1H), 8.4 (s, 1H), 7.65 (m, 1H), 6.52 (m, 1H). MS: m/z 230.8/232.8 (M+H+).
後処理
- temperatureto warm to 23° C. over 1 h after which it
- temperaturewas cooled on an ice bath
- customquenched with water (800 mL)
- filtrationThe solids were filtered
- customrecrystallized from ethyl acetate and hexanes
出典と根拠
- ORDレコード
- ord-0197c0c0b3b341c4bc7d0f3f12b08353
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158647B2
反応ノート
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