Hydrochloric Acid → 4-[(Phenylsulfanyl)methyl]benzoic acid

HRID 1694191

反応式

HRID 1694191 の反応式
Br[CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[S-:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[Na+].Cl>C(O)C>[C:13]1([S:12][CH2:2][C:3]2[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 225994-(Bromomethyl)benzoic acidHCID 4110039Sodium benzenethiolate

生成物 1

HCID 8758244-[(Phenylsulfanyl)methyl]benzoic acid収率 88%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-(bromomethyl)benzoic acid (10 g, 46.5 mmol), sodium thiophenoxide (6.15 g, 46.5 mmol), and ethanol (100 mL) was stirred for 1.5 hours under reflux. This mixture was cooled to room temperature and acidified with 1 N hydrochloric acid. The precipitate thus produced was collected, dissolved in ethyl acetate, and washed with water. The organic layer was concentrated under a reduced pressure to obtain the title compound (10 g). The title compound was used in the following reaction without any further purification.

後処理

  1. temperatureunder reflux
  2. customThe precipitate thus produced
  3. customwas collected
  4. dissolutiondissolved in ethyl acetate
  5. washwashed with water
  6. concentrationThe organic layer was concentrated under a reduced pressure

出典と根拠

ORDレコード
ord-02557a85514a465fa7c99ded696ca056
出典データセット
uspto-grants-2012_04
特許番号
US08158657B2

関連ノート

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