(4-Methoxyphenyl)boronic acid → tert-Butyl [(5-chloro-4'-methoxybiphenyl-2-yl)oxy]acetate

反応式

[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)([CH3:4])([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:17])=[C:10]([C:23]2[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=2)[CH:11]=1

参加物

反応物 2

HCID 201262(4-Methoxyphenyl)boronic acid

HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

生成物 1

HCID 86654987tert-Butyl [(5-chloro-4'-methoxybiphenyl-2-yl)oxy]acetate

実験手順

The subtitle compound was prepared by the method of example 1 step (ii) using the product from example 1 step (i) and 4-methoxyphenylboronic acid. Yield 0.610 g

出典と根拠

ORDレコード: ord-f5c8bc10e01d463eb3867e251ffb3044
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08158820B2

反応ノート

読み込み中…