3,4-Dimethoxyphenylboronic acid → tert-Butyl [(5-chloro-3',4'-dimethoxybiphenyl-2-yl)oxy]acetate

反応式

[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)([CH3:4])([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:17])=[C:10]([C:23]2[CH:22]=[CH:21][C:20]([O:19][CH3:18])=[C:25]([O:26][CH3:27])[CH:24]=2)[CH:11]=1

参加物

反応物 2

HCID 27347023,4-Dimethoxyphenylboronic acid

HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

生成物 1

HCID 86654988tert-Butyl [(5-chloro-3',4'-dimethoxybiphenyl-2-yl)oxy]acetate

実験手順

The subtitle compound was prepared by the method of example 1 step (ii) using the product from example 1 step (i) and 3,4-dimethoxyphenylboronic acid. Yield 0.86 g

出典と根拠

ORDレコード: ord-b159cb6f7b744aaea513622bbd3e76e2
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08158820B2

反応ノート

読み込み中…