CS[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=2[O:19][CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[C:5]([C:28]([F:31])([F:30])[F:29])[CH:4]=1.[C:32](=O)(O)[O-].[Na+].O[O:38][S:39]([O-:41])=O.[K+]>CC(C)=O.O>[CH3:32][S:39]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:12]=[CH:11][C:10]=2[O:19][CH2:20][C:21]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:22])=[C:5]([C:28]([F:29])([F:30])[F:31])[CH:4]=1)(=[O:41])=[O:38]The product from step (iv) (0.564 g) was dissolved in 50% aqueous acetone (10 ml), sodium bicarbonate (0.94 g) added, followed by a solution of oxone (1.5 g) in water (ml) and stirred for 3 h. The reaction was quenched with aqueous sodium metabisulfite, extracted with EtOAc, washed with aqueous potassium carbonate, dried (Na2SO4) and evaporated to give the subtitle compound. Yield 0.32 g.
読み込み中…