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Methyl iodide → N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide | HCID 67280818 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide | HCID 67280607 | — |
反応手順
The product from step (i) (2.23 g), potassium carbonate (2.33 g) and methyl iodide (0.7 ml) were stirred in DMF (20 ml) for 20 h. The reaction was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane. Yield 1.5 g. Carried forward to step (ii) without characterisation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08158820B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-162851ddd35c48c4be538806b1fc5bdf |
| 出典メモ | uspto-grants-2012_04 |