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Methylamine → 4-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | HCID 178508950 | HCID 178508950 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine | HCID 178509863 | — |
反応手順
Trifluoroacetamide 49 (Example 32, 15.1 mg, 0.019 mmol) are dissolved in 1 mL methanol, and 2 mL methylamine (33% in ethanol) are added. The reaction mixture is stirred at room temperature for 48 h and all volatiles are removed in vacuo. The product is used without further purification. MS (ESI) m/z 667.5 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163479B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-6a442575b20c422eaabb803b44b96fad |
| 出典メモ | uspto-grants-2012_04 |