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HRID 1695156作成日:2026年10月27日

(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

https://huagongshe.com/reaction/1695156

反応式

関与物質

役割名称HCID仕込み量
反応物(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11539174—
反応物(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67277298—
生成物(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11538441—

反応手順

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08163727B2
出典データセットuspto-grants-2012_04
ORD IDord-8bd2a9ec66754e9b99909a43a39f7273
出典メモuspto-grants-2012_04