Methyl 2-Chloro-4-fluorobenzoate → 2-Chloro-4-fluoro-β-oxobenzenepropanenitrile

反応式

[NH2:1][C:2]1[CH:6]=CNN=1.CO[C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[Cl:17]>>[Cl:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[C:9](=[O:18])[CH2:6][C:2]#[N:1]

参加物

反応物 2

HCID 2763551Methyl 2-Chloro-4-fluorobenzoate

HCID 178418806HCID 178418806、化合物

生成物 1

HCID 246916312-Chloro-4-fluoro-β-oxobenzenepropanenitrile収率 60%

実験手順

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 2-chloro-4-fluoro-benzoic acid methyl ester (0.7 g, 3.7 mmol, 1.0 eq). The crude product was extracted with DCM and used in the following step without further purification (0.4 g, yield: 60%).

後処理

customThe product was prepared
extractionThe crude product was extracted with DCM
customused in the following step without further purification (0.4 g, yield: 60%)

出典と根拠

ORDレコード: ord-35497e4c044a4424b7ba33b570138664
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08163729B2

反応ノート

読み込み中…

参加物