化工社化工社 化学情報印刷レポート · 研究参考用
Propionitrile → 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propionitrile | HCID 7854 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 反応物 | HCID 178418806 | HCID 178418806 | — |
| 生成物 | 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile | HCID 43157266 | 96% |
反応手順
The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 4-trifluoromethyl-benzoic acid methyl ester (3.0 g, 14.7 mmol, 1.0 eq), NaH (1.2 g, 29.4 mmol, 2.0 eq) and propionitrile (4.9 mL, 69.4 mmol, 4.7 eq). The crude product was extracted with DCM and used in the following step without further purification (3.2 g, yield: 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163729B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-bd720de13d4141079f412edd57df2be6 |
| 出典メモ | uspto-grants-2012_04 |