HCID 17887686、化合物 → 3-(Difluoromethoxy)-β-oxobenzenepropanenitrile

反応式

[NH2:1][C:2]1[CH:6]=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:33]([F:35])[F:34])[CH:27]=1>>[F:35][CH:33]([F:34])[O:32][C:28]1[CH:27]=[C:26]([C:25](=[O:36])[CH2:6][C:2]#[N:1])[CH:31]=[CH:30][CH:29]=1

参加物

反応物 3

HCID 17887686HCID 17887686、化合物

HCID 67015924HCID 67015924、化合物

HCID 178418806HCID 178418806、化合物

生成物 1

HCID 431238303-(Difluoromethoxy)-β-oxobenzenepropanenitrile

実験手順

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1 bis) from 3-difluoromethoxy-benzoic acid methyl ester (1.5 g, 7.4 mmol, 1.0 eq). The crude was precipitated by addition of aqueous HCl to give the product which was used directly for the next step.