3-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrile → HCID 178462497、化合物

HRID 1695238ノート

反応式

HRID 1695238 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[CH2:7]([N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](C(=O)CC#N)=[CH:10]1)[CH3:8]>>[CH2:7]([N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([C:5]2[CH:6]=[C:2]([NH2:1])[NH:3][N:4]=2)=[CH:10]1)[CH3:8]

参加物

3

反応物 2

HCID 671880253-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrileHCID 178418806HCID 178418806、化合物

生成物 1

HCID 178462497HCID 178462497、化合物収率 70%

実験手順

The product was prepared according to general procedure for aminopyrazole synthesis (route A2) starting from 3-(1-ethyl-1H-indol-3-yl)-3-oxo-propionitrile (820 mg, 3.87 mmol, 1.0 eq). The solvent was removed under reduced pressure; the solid residue was washed with EtOH to obtain the title product (612 mg, 70% yield).

後処理

  1. customThe product was prepared
  2. customThe solvent was removed under reduced pressure
  3. washthe solid residue was washed with EtOH

出典と根拠

ORDレコード
ord-8ad9340eb697481390c7c7aeaf98867b
出典データセット
uspto-grants-2012_04
特許番号
US08163729B2

反応ノート

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