化工社化工社 化学情報印刷レポート · 研究参考用
Formate → HCID 178520650、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formate | HCID 283 | — |
| 反応物 | Butyric acid, 4-piperidino- | HCID 20794 | — |
| 反応物 | HCID 178507293 | HCID 178507293 | — |
| 生成物 | HCID 178520650 | HCID 178520650 | 28% |
反応手順
The product was prepared according to the general synthetic method for the synthesis of ω-amino-alkanoic acid (1H-pyrazol-3-yl-5-aryl)-amides via the amino acid route, starting from 5-(4-cyclopropylmethoxy-phenyl)-2H-pyrazol-3-ylamine (152.9 mg, 0.7 mmol, 1.0 eq) and 4-piperidin-1-yl-butyric acid (168 mg, 1.0 mmol, 1.5 eq). The crude product was purified via preparative HPLC; 72.0 mg of the title product (28% yield) was obtained as a formate salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163729B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-72fb51b6e0614cacb579e72814fe1012 |
| 出典メモ | uspto-grants-2012_04 |