Methanol → Methyl 2-(difluoromethoxy)benzoate

HRID 1695245ノート

反応式

HRID 1695245 の反応式
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[O:3][CH:2]([F:13])[F:1]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 20633482-(Difluoromethoxy)benzoic acid

生成物 1

HCID 7018382Methyl 2-(difluoromethoxy)benzoate収率 87%

実験手順

2.0 g of 2-difluoromethoxy-benzoic acid (10.6 mmol, 1.0 eq) were dissolved in MeOH (15 mL) and a catalytic quantity of sulfuric acid was added; the mixture was heated at reflux overnight. The solvent was then evaporated and the residue was dissolved in DCM and washed with saturated NaHCO3. The organic phase was dried and evaporated to give 1.9 g of title product (yield 87%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customThe solvent was then evaporated
  4. dissolutionthe residue was dissolved in DCM
  5. washwashed with saturated NaHCO3
  6. customThe organic phase was dried
  7. customevaporated

出典と根拠

ORDレコード
ord-efde82da3b744d7a978bcc6d18f39944
出典データセット
uspto-grants-2012_04
特許番号
US08163729B2

反応ノート

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