1-Methyl-3-aminopyrazole → HCID 59568423、化合物

反応式

CO[C:3]([C:5]1[N:6]([CH3:26])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[N:14][O:15][C:16]=2[CH2:17][OH:18])[CH:9]=1)=[O:4].[CH3:27][N:28]1[CH:32]=[CH:31][C:30]([NH2:33])=[N:29]1>>[CH3:27][N:28]1[CH:32]=[CH:31][C:30]([NH:33][C:3]([C:5]2[N:6]([CH3:26])[N:7]=[C:8]([O:10][CH2:11][C:12]3[C:13]([C:19]4[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=4)=[N:14][O:15][C:16]=3[CH2:17][OH:18])[CH:9]=2)=[O:4])=[N:29]1

参加物

反応物 2

HCID 1372541-Methyl-3-aminopyrazole

HCID 66643735HCID 66643735、化合物

生成物 1

HCID 59568423HCID 59568423、化合物収率 68%

実験手順

As described for example 91h, 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.28 mmol) was converted, using 1-methyl-1H-pyrazol-3-ylamine instead of 4-aminotetrahydropyran, to the title compound (80 mg, 68%) which was obtained as a white solid. MS: m/e=425.1 [M−H]−.

出典と根拠

ORDレコード: ord-e90bd7129acf42b480579eb55e04e47c
出典データセット: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08163728B2

反応ノート

読み込み中…

参加物