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4-Aminotetrahydropyran → HCID 49793179、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 反応物 | 1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester | HCID 66646333 | — |
| 生成物 | HCID 49793179 | HCID 49793179 | 90% |
反応手順
As described for example 115, 1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester (70 mg, 0.21 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (76 mg, 90%) which was obtained as a colorless oil. MS: m/e=398.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163728B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-696ed96c64e044eb89db345eedc7a775 |
| 出典メモ | uspto-grants-2012_04 |