ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

5-Bromo-N-methylpyridine-3-sulfonamide → HCID 44539624、化合物

HRID 1695806
ノート
印刷プレビュー

反応式

HRID 1695806 の反応式
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH:9][C:10]2[CH:18]=[C:17]([Sn](C)(C)C)[CH:16]=[C:15]3[C:11]=2[CH:12]=[N:13][N:14]3S(C2C=CC=CC=2)(=O)=O)=[O:8])[N:6]=1.Br[C:33]1[CH:34]=[C:35]([S:39]([NH:42][CH3:43])(=[O:41])=[O:40])[CH:36]=[N:37][CH:38]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CN(C=O)C>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH:9][C:10]2[CH:18]=[C:17]([C:33]3[CH:38]=[N:37][CH:36]=[C:35]([S:39]([NH:42][CH3:43])(=[O:40])=[O:41])[CH:34]=3)[CH:16]=[C:15]3[C:11]=2[CH:12]=[N:13][NH:14]3)=[O:8])[N:6]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 467389795-Bromo-N-methylpyridine-3-sulfonamideHCID 582558202-Methyl-N-[1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide

生成物 1

HCID 44539624HCID 44539624、化合物収率 3.9%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 6228
Dimethylformamide
溶媒

反応条件

温度
120 °C

実験手順

2-Methyl-N-[1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide (50 mg) was placed in microwave vial with Pd(PPh3)4 (10 mg) and 5-bromo-N-methyl-3-pyridinesulfonamide (24.6 mg) was added. DMF (2 ml) was added and the reaction was heated under microwave irradiation for 15 min at 120° C. The reaction was evaporated to dryness and the residue was dissolved in IPA (2 ml) and 2M NaOH (aq) (1 ml). The reaction was stirred at RT for 3 h then evaporated to dryness. The residue was purified by MDAP (method E) to give the title compound (1.5 mg).

後処理

  1. additionwas added
  2. customThe reaction was evaporated to dryness
  3. dissolutionthe residue was dissolved in IPA (2 ml)
  4. customthen evaporated to dryness
  5. customThe residue was purified by MDAP (method E)

出典と根拠

ORDレコード
ord-80b0e61404ba4d6d92bc24342b6810ce
出典データセット
uspto-grants-2012_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08163743B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート