3,3-Dimethylbutylamine → HCID 178444764、化合物

HRID 1695930ノート

反応式

HRID 1695930 の反応式
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:11]=2[CH:12]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22][NH2:23]>C1(C)C=CC=CC=1>[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22]/[N:23]=[CH:12]/[C:11]1[CH:14]=[CH:15][CH:16]=[C:17]([F:18])[C:10]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 197093,3-DimethylbutylamineHCID 577744132-(2-(Piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde

生成物 1

HCID 178444764HCID 178444764、化合物収率 95.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Crude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde (372 mg, 1.486 mmol) and 3,3-dimethylbutan-1-amine (225.6 mg, 300.0 μL, 2.229 mmol) were stirred in toluene (7 mL) with 4A MS at RT overnight. The mixture was filtered and the volatiles were removed on rotary evaporator at 40° C. to give 475 mg of crude 2-((E)-(3,3-dimethylbutylimino)methyl)-6-fluoro-N-(2-(piperidin-1-yl)ethyl)benzenamine which was used directly in the next step.

後処理

  1. filtrationThe mixture was filtered
  2. customthe volatiles were removed on rotary evaporator at 40° C.

出典と根拠

ORDレコード
ord-a3061cb10b7e44e583edfa5987822f99
出典データセット
uspto-grants-2012_04
特許番号
US08163737B2

反応ノート

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