化工社化工社 化学情報印刷レポート · 研究参考用
(s)-2-Mercaptosuccinic acid → 2-(2-(2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (s)-2-Mercaptosuccinic acid | HCID 3246154 | — |
| 反応物 | HCID 178483753 | HCID 178483753 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(2-(2-(2-(Dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid | HCID 76601992 | — |
反応手順
2-((E)-(3,3-dimethylbutylimino)methyl)-N-(2-(dimethylamino)ethyl)-6-fluorobenzenamine (175 mg, 0.5964 mmol) and (S)-2-mercaptosuccinic acid (102 mg, 0.6793 mmol) were stirred in toluene (7 mL) at 80° C. for 24 hours. Crude 2-(2-(2-(2-(dimethylamino)ethylamino)-3-fluorophenyl)-3-(3,3-dimethylbutyl)-4-oxothiazolidin-5-yl)acetic acid was obtained as a brown oil and carried on to the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163737B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-87266a0698224c2dbd67da46cfd3d94f |
| 出典メモ | uspto-grants-2012_04 |