3,3-Dimethylbutylamine → N-(2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzylidene)-3,3-dimethylbutan-1-amine

HRID 1695947

反応式

HRID 1695947 の反応式
[F:1][C:2]1([F:16])[CH2:6][CH2:5][N:4]([C:7]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:8]=2[CH:9]=O)[CH2:3]1.[CH3:17][C:18]([CH3:23])([CH3:22])[CH2:19][CH2:20][NH2:21]>C1(C)C=CC=CC=1>[F:1][C:2]1([F:16])[CH2:6][CH2:5][N:4]([C:7]2[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:8]=2[CH:9]=[N:21][CH2:20][CH2:19][C:18]([CH3:23])([CH3:22])[CH3:17])[CH2:3]1

参加物

4

反応物 2

HCID 197093,3-DimethylbutylamineHCID 577744763-Fluoro-2-(3,3-difluoropyrrolidin-1-yl)benzaldehyde

生成物 1

HCID 57774377N-(2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzylidene)-3,3-dimethylbutan-1-amine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2-(3,3-Difluoropyrrolidin-1-yl)-3-fluorobenzaldehyde (400 mg, 1.745 mmol) was taken in toluene (15 mL) and 3,3-dimethylbutan-1-amine (176.6 mg, 234.8 μL, 1.745 mmol) was added. The reaction mixture was refluxed overnight with a Dean Stark trap to remove the water. The reaction mixture was then concentrated and used in the next step without further purification.

後処理

  1. temperatureThe reaction mixture was refluxed overnight with a Dean Stark trap
  2. customto remove the water
  3. concentrationThe reaction mixture was then concentrated
  4. customused in the next step without further purification

出典と根拠

ORDレコード
ord-6f87a974a25e48bb917e3f4d0fb7e90f
出典データセット
uspto-grants-2012_04
特許番号
US08163737B2

関連ノート

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