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HRID 1695963作成日：2026年10月27日
Ethanol → 4-(3-Isoxazol-5-yl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide
https://huagongshe.com/reaction/1695963
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515576 | — |
| 反応物 | 3-Isoxazol-5-yl-3-oxo-propionic acid ethyl ester | HCID 59515581 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-(3-Isoxazol-5-yl-5-oxo-2,5-dihydro-pyrazol-1-yl)-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide | HCID 59515579 | — |
反応手順
3-Isoxazol-5-yl-3-oxo-propionic acid ethyl ester (49 mg) and 4-Hydrazino-N-(1,2,2,6,6-pentamethyl-piperidin-4-yl)-benzamide (93 mg) were dissolved into ethanol (2.5 ml) and acetic acid (0.3 ml) and the solution stirred at 65° C. for 2 h. Concentration in vacuo and purification by HPLC gave the expected product. LC/MS: main peak is product (m/z: 424.3)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08163757B2 |
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| 出典データセット | uspto-grants-2012_04 |
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| ORD ID | ord-b749f24f24fe4fcba056b5e8b41063bc |
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| 出典メモ | uspto-grants-2012_04 |
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