Ethyl 4-hydrazinylbenzoate → HCID 58945244、化合物

HRID 1696600ノート

反応式

HRID 1696600 の反応式
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1)[CH3:2].[CH3:14][CH:15]([CH3:21])[C:16](=O)[CH2:17][C:18]#[N:19]>>[NH2:19][C:18]1[N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:13])=[CH:6][CH:7]=2)[N:12]=[C:16]([CH:15]([CH3:21])[CH3:14])[CH:17]=1

参加物

3

反応物 2

HCID 792992Ethyl 4-hydrazinylbenzoateHCID 101299214-Methyl-3-oxopentanenitrile

生成物 1

HCID 58945244HCID 58945244、化合物収率 88.2%

実験手順

Using the same method as Example A83, 4-hydrazinobenzoic acid ethyl ester (from Example A82, 3 g, 16.6 mmol) and 4-methyl-3-oxopentanenitrile (from Example A83, 2.7 g, 27.9 mmol) were combined to afford ethyl 4-(5-amino-3-isopropyl-1H-pyrazol-1-yl)benzoate (4 g, 88% yield), which was used to the next reaction without further purification.

出典と根拠

ORDレコード
ord-aa8f878fa0ed4735a7efdddb7ee91279
出典データセット
uspto-grants-2012_04
特許番号
US08163756B2

反応ノート

読み込み中…