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4-Chlorobenzoyl chloride → 4-chloro-N-(3-formylphenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| 反応物 | Benzaldehyde, 3-amino- | HCID 74366 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-chloro-N-(3-formylphenyl)benzamide | HCID 2375093 | 129% |
反応手順
to a solution of 242 mg of 3-aminobenzaldehyde (2 mmoles) and 250 μl of 4-chlorobenzoyl chloride (2 mmoles) in 5 ml of DMF is added 700 μl of DIEA (4 mmoles). The reaction is irradiated in under microwaves at 110° C. for 10 minutes. The precipitate formed is filtrated and washed with methanol. 670 mg of 4-Chloro-N-(3-formyl-phenyl)-benzamide are isolated as a white solid (yield=85%). Analytical LC/MS method A: ([M+H]+): 260
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163768B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-05054a6e1adc4eb8bca736275ffa08ab |
| 出典メモ | uspto-grants-2012_04 |