Ammonia → 6-Bromo-4-methoxypyridin-2-amine

HRID 1696785ノート

反応式

HRID 1696785 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4](Br)[N:3]=1.[NH3:11]>>[Br:1][C:2]1[N:3]=[C:4]([NH2:11])[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 109015692,6-Dibromo-4-methoxypyridine

生成物 1

HCID 714642286-Bromo-4-methoxypyridin-2-amine

実験手順

A solution of 2.00 g 2,6-dibromo-4-methoxy-pyridine in 80 g liquid ammonia under was heated in an autoclave to 140° C. for 4 h. The reaction was cooled to room, evaporated and the residue was purified by silica column chromatography to yield 0.457 g of the title compound as white solid. MS (ISP) M+H+=203.2 205.5

後処理

  1. temperatureThe reaction was cooled to room
  2. customevaporated
  3. customthe residue was purified by silica column chromatography

出典と根拠

ORDレコード
ord-b47c46a805b049e88c6d4390cbb4a4e9
出典データセット
uspto-grants-2012_04
特許番号
US08163778B2

反応ノート

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