Hydrochloric Acid → (3S)-1-(pyridin-2-yl)pyrrolidin-3-amine dihydrochloride
反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1.CO>[ClH:20].[ClH:20].[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1参加物
5
実験手順
To a solution of ((S)-1-pyridin-2-yl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester (0.221 g, 0.84 mmol) in dioxane (4 ml) and methanol (1 ml) is added 4M HCl (in dioxane) (0.525 ml, 2.1 mmol) and the reaction mixture is stirred at room temperature overnight. The resulting suspension is filtered and washed with dioxane (3×1 ml) to yield the titled compound.
後処理
- filtrationThe resulting suspension is filtered
- washwashed with dioxane (3×1 ml)
出典と根拠
- ORDレコード
- ord-d91c1a81bd5342dfb12cfb43bee656b5
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163754B2
反応ノート
読み込み中…