2-Oxopropanoyl chloride → N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide

HRID 1697085ノート

反応式

HRID 1697085 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:26])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([NH:20][CH2:21][C:22]([OH:25])([CH3:24])[CH3:23])(=[O:19])=[O:18])=[CH:13][CH:12]=2)=[C:4]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:3]=1.[O:34]=[C:35]([CH3:39])[C:36](Cl)=[O:37]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:26])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([S:17](=[O:19])(=[O:18])[NH:20][CH2:21][C:22]([OH:25])([CH3:24])[CH3:23])=[CH:13][CH:12]=2)=[C:4]([N:27]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:36](=[O:37])[C:35](=[O:34])[CH3:39])[CH:3]=1

参加物

4

反応物 2

HCID 5217912-Oxopropanoyl chlorideHCID 598461744-[3-(4-chloro-2-phenylaminophenyl)-3-oxo-propyl]-N-(2-hydroxy-2-methylpropyl)-benzenesulfonamide

生成物 1

HCID 59846199N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
120 °C

実験手順

To 4-[3-(4-chloro-2-phenylaminophenyl)-3-oxo-propyl]-N-(2-hydroxy-2-methylpropyl)-benzenesulfonamide (0.138 g) in toluene (10 mL) was added 2-oxopropionyl chloride (0.3 mL), and the mixture heated at 120° C. for 3 h to form N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide, which was used without further purification.

出典と根拠

ORDレコード
ord-1d1589d85a1b4355b0ee3418bc1b8af7
出典データセット
uspto-grants-2012_04
特許番号
US08163906B2

反応ノート

読み込み中…