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HRID 1697184作成日：2026年10月26日

4-Iodo-2-(trifluoromethyl)pyridine → (S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

https://huagongshe.com/reaction/1697184

反応式

関与物質

役割名称HCID仕込み量
反応物4-Iodo-2-(trifluoromethyl)pyridineHCID 23436940—
反応物(R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoateHCID 86614124—
生成物(S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoateHCID 67165305—

反応手順

The title compound was prepared according to previously reported procedure (see pending U.S. patent application Ser. No. 11/575,187) from (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-iodo-2-(trifluoromethyl)pyridine (this starting material was prepared according to a procedure described in Eur. J. Org. Chem. 2003, 1559-1568).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08163909B2
出典データセットuspto-grants-2012_04
ORD IDord-cbebf66771c04952bc7e7dd7c5332e4f
出典メモuspto-grants-2012_04