Ammonia → 2-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

HRID 1697328

反応式

HRID 1697328 の反応式
[CH3:1][C:2]1([CH3:12])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:11].[NH3:13]>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:2]([CH3:12])([CH3:1])[C:3]([NH2:13])=[O:11]

参加物

4

反応物 2

HCID 222AmmoniaHCID 5956202(3H)-Benzofuranone, 3,3-dimethyl-

生成物 1

HCID 866632482-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

3,3-Dimethylbenzofuran-2(3H)-one (Example 198a, 19.7 g) was dissolved in 7N ammonia in methanol (50 mL) under nitrogen. The resulting solution was stirred at 25° C. for 16 h. The reaction mixture was evaporated to afford crude product. The solid was triturated with diethyl ether and filtered to give the subtitle compound (15.34 g).

後処理

  1. customThe reaction mixture was evaporated
  2. customto afford crude product
  3. customThe solid was triturated with diethyl ether
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-507d9bb5aaf2476ea2cb8e36ea591080
出典データセット
uspto-grants-2012_04
特許番号
US08163905B2

関連ノート

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