化工社化工社 化学情報印刷レポート · 研究参考用
1-Isopropylhydrazine hydrochloride → (2S,4R)-1-(2-isopropyl-5-methyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Isopropylhydrazine hydrochloride | HCID 85573 | — |
| 反応物 | (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646823 | — |
| 生成物 | (2S,4R)-1-(2-isopropyl-5-methyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66771090 | — |
反応手順
In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with isopropylhydrazine hydrochloride (CAS Reg. No. 16726-41-3) to give the title compound as yellow solid. MS (ESI): m/z=460.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163793B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-ff8bd61c448046f899a8258713dc4c97 |
| 出典メモ | uspto-grants-2012_04 |