Lawesson's reagent → (2S,4R)-1-(2-Cyclohexyl-5-methyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

反応式

C(C1(NC([C@@H]2C[C@@H](S(C3C=CC=CC=3C(F)(F)F)(=O)=O)CN2C2N(C3C=CC=CC=3)N=C(C)C=2)=O)CC1)#N.COC([C@H]1C[C@@H](S(C2C=CC=CC=2C(F)(F)F)(=O)=O)CN1C(=O)CC(=O)C)=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=S)=CC=1.Cl.C1(NN)CCCCC1.[CH3:98][O:99][C:100]([C@H:102]1[CH2:106][C@@H:105]([S:107]([C:110]2[CH:115]=[CH:114][CH:113]=[CH:112][C:111]=2[C:116]([F:119])([F:118])[F:117])(=[O:109])=[O:108])[CH2:104][N:103]1[C:120]1[N:121]([CH:126]2[CH2:131][CH2:130][CH2:129][CH2:128][CH2:127]2)[N:122]=[C:123]([CH3:125])[CH:124]=1)=[O:101]>>[CH3:98][O:99][C:100]([C@@H:102]1[CH2:106][C@@H:105]([S:107]([C:110]2[CH:115]=[CH:114][CH:113]=[CH:112][C:111]=2[C:116]([F:119])([F:117])[F:118])(=[O:109])=[O:108])[CH2:104][N:103]1[C:120]1[N:121]([CH:126]2[CH2:131][CH2:130][CH2:129][CH2:128][CH2:127]2)[N:122]=[C:123]([CH3:125])[CH:124]=1)=[O:101]