Benzylhydrazine dihydrochloride → (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

HRID 1697653ノート

反応式

HRID 1697653 の反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20](=S)[CH2:21][C:22](=O)[CH3:23])=[O:4].Cl.Cl.[CH2:28]([NH:35][NH2:36])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:11])=[O:12])[CH2:7][N:6]1[C:20]1[N:35]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:36]=[C:22]([CH3:23])[CH:21]=1)=[O:4]

参加物

3

反応物 2

HCID 146540Benzylhydrazine dihydrochlorideHCID 86646820(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate

生成物 1

HCID 66770380(2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

実験手順

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with benzylhydrazine dihydrochloride (CAS Reg. No. 20570-96-1) to give the title compound as orange oil. MS (ESI): m/z=474.2 [M+H]+.

出典と根拠

ORDレコード
ord-a2ddb2a2f2c74ba0852bc00d590387ab
出典データセット
uspto-grants-2012_04
特許番号
US08163793B2

反応ノート

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