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HRID 1697672作成日：2026年10月27日

(Oxan-4-yl)hydrazine hydrochloride → (2S,4R)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(tetrahydro-pyran-4-yl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

https://huagongshe.com/reaction/1697672

反応式

関与物質

役割名称HCID仕込み量
反応物(Oxan-4-yl)hydrazine hydrochlorideHCID 17773358—
反応物(2S,4R)-4-(4-Fluoro-2-trifluoromethyl-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic Acid Methyl EsterHCID 86646829—
生成物(2S,4R)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(tetrahydro-pyran-4-yl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl EsterHCID 67278636—

反応手順

In analogy to the procedure described in example 192 h, (2S,4R)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 388 d) was reacted with (tetrahydro-pyran-4-yl)-hydrazine hydrochloride (CAS Reg. No. 116312-69-7) to give the title compound as brown solid. MS (ESI): m/z=520.3 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08163793B2
出典データセットuspto-grants-2012_04
ORD IDord-8dfdf928a1d948a1963c4d24d4e862fb
出典メモuspto-grants-2012_04