Cyclobutylhydrazine--hydrogen chloride (1/1) → (2S,4R)-1-[2-Cyclobutyl-5-(tetrahydro-pyran-4-yl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=S)[CH2:24][C:25](=O)[CH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1)=[O:4].Cl.[CH:35]1([NH:39][NH2:40])[CH2:38][CH2:37][CH2:36]1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:11])=[O:12])[CH2:7][N:6]1[C:23]1[N:39]([CH:35]2[CH2:38][CH2:37][CH2:36]2)[N:40]=[C:25]([CH:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[CH:24]=1)=[O:4]参加物
3
反応物 2
生成物 1
実験手順
In analogy to the procedure described in example 192 h, (2S,4R)-1-[3-oxo-3-(tetrahydro-pyran-4-yl)-thiopropionyl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 393d) was reacted with cyclobutylhydrazine hydrochloride (CAS Reg. No. 158001-21-9) to give the title compound as yellow oil. MS (ESI): m/z=542.4 [M+H]+.