(4-Chlorobenzyl)hydrazine → (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(4-chloro-benzyl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

HRID 1697703ノート

反応式

HRID 1697703 の反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20](=S)[CH2:21][C:22](=O)[CH3:23])=[O:4].[Cl:26][C:27]1[CH:35]=[CH:34][C:30]([CH2:31][NH:32][NH2:33])=[CH:29][CH:28]=1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20]1[N:32]([CH2:31][C:30]2[CH:34]=[CH:35][C:27]([Cl:26])=[CH:28][CH:29]=2)[N:33]=[C:22]([CH3:23])[CH:21]=1)=[O:4]

参加物

3

反応物 2

HCID 3015209(4-Chlorobenzyl)hydrazineHCID 86646820(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate

生成物 1

HCID 67277851(2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(4-chloro-benzyl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

実験手順

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with (4-chloro-benzyl)-hydrazine (CAS Reg. No. 25198-45-2) to give the title compound as orange oil. MS (ESI): m/z=508.0 [M+H]+.

出典と根拠

ORDレコード
ord-2dff5fef956e4e65a1ccd98c36b68e2b
出典データセット
uspto-grants-2012_04
特許番号
US08163793B2

反応ノート

読み込み中…