Tert-butyl acetoacetate → (2S,4R)-4-Methanesulfonyl-1-(3-oxo-butyryl)-pyrrolidine-2-carboxylic Acid Methyl Ester
反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]([C@@H:12]1[CH2:16][C@@H:15]([S:17]([CH3:20])(=[O:19])=[O:18])[CH2:14][NH:13]1)=[O:11].[C:21](OC(C)(C)C)(=[O:26])[CH2:22][C:23]([CH3:25])=[O:24]>C(N(CC)CC)C>[CH3:8][O:9][C:10]([C@@H:12]1[CH2:16][C@@H:15]([S:17]([CH3:20])(=[O:19])=[O:18])[CH2:14][N:13]1[C:21](=[O:26])[CH2:22][C:23](=[O:24])[CH3:25])=[O:11]参加物
4
実験手順
In analogy to the procedure described in example 192f, (2S,4R)-4-methanesulfonyl-pyrrolidine-2-carboxylic acid methyl ester trifluoroacetate was reacted with tert-butyl acetoacetate in the presence of triethylamine to give the title compound. MS (ESI): m/z=292.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-6d654a7b73d9489fa07b89432f1b0b3e
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08163793B2
反応ノート
読み込み中…