Hydrochloric Acid → (3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

HRID 1698220ノート

反応式

HRID 1698220 の反応式
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644、化合物

生成物 1

HCID 21292272(3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

後処理

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-46796126241e4eaba574ee372fa87aef
出典データセット
uspto-grants-2012_04
特許番号
US08163918B2

反応ノート

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