(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide → (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-amino-2-hydroxyheptanamide

HRID 1698441ノート

反応式

HRID 1698441 の反応式
[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([NH:12][C:13](=[O:24])[C@@H:14]([OH:23])[C@@H:15]([N:20]=[N+]=[N-])[CH2:16][CH2:17][CH2:18][CH3:19])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>[C].[Pd].CO>[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([NH:12][C:13](=[O:24])[C@@H:14]([OH:23])[C@@H:15]([NH2:20])[CH2:16][CH2:17][CH2:18][CH3:19])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 1

HCID 59655559(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide

生成物 1

HCID 59655562(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-amino-2-hydroxyheptanamide収率 94%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To 30 ml of a methanol solution containing 442 mg (1.27 mmol) of (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide was added 45 mg of 5% palladium carbon, and the mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 385 mg (Yield: 94%) of the title compound.

後処理

  1. filtrationInsoluble materials were filtered off
  2. distillationthe filtrate was distilled under reduced pressure

出典と根拠

ORDレコード
ord-430a7a9f1e0946babc589c7a7b8007d3
出典データセット
uspto-grants-2012_04
特許番号
US08163943B2

反応ノート

読み込み中…