関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazine | HCID 98698 | — |
| 反応物 | 2-(3-Chloroprop-1-yl)-3,3-dimethyl-2,3-dihydro-1,2-benzoisothia-zole 1,1-dioxide | HCID 70162324 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(1-Piperazinyl)isoquinoline | HCID 11769830 | 43% |
反応手順
1.1 g (5.2 mmol) of 1-(5-tetralinyl)piperazine, 1.5 ml of triethylamine and a trace of potassium iodide were added to a solution of 1.64 g (6.0 mmol) of 2-(3-chloroprop-1-yl)-3,3-dimethyl-2,3-dihydro-1,2-benzoisothiazole 1,1-dioxide in 40 ml of DMF. The reaction mixture was stirred at 100° C. for four hours and then poured in ice-water, and the resulting precipitate was filtered off with suction. Purification took place by recrystallization from isopropanol to result in 1 g (43%) of the product (melting point 140° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06346622B1 |
|---|
| 出典データセット | uspto-grants-2002_02 |
|---|
| ORD ID | ord-aee5bd8e029843db9cf1beeb61ee1bf1 |
|---|
| 出典メモ | uspto-grants-2002_02 |
|---|
