Water → Dihydroartemisinin ethyl ether

HRID 1699475

反応式

HRID 1699475 の反応式
[CH3:1][C@H:2]1[C@@H:11]2[CH2:12][CH2:13][C:14]3([CH3:18])[O:16][O:17][C@:10]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:19])[O:8][C@@H:9]4[O:15]3)[CH2:4][CH2:3]1.[CH2:21](OC(OCC)OCC)[CH3:22].O>C(O)C>[CH3:21][CH2:22][O:19][C@H:7]1[O:8][C@@H:9]2[O:15][C:14]3([CH3:18])[O:16][O:17][C@@:10]42[C@@H:5]([CH2:4][CH2:3][C@@H:2]([CH3:1])[C@@H:11]4[CH2:12][CH2:13]3)[C@H:6]1[CH3:20]

参加物

5

反応物 3

HCID 962WaterHCID 31214Ethyl orthoformateHCID 456410Npc182939

生成物 1

HCID 72416Dihydroartemisinin ethyl ether

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

Dihydroartemisinin (50 mg) was dissolved in dry ethanol (3 ml) In the reaction mixture ptoluene sulphonic acid (25 mg) and triethylorthoformate (2 ml) was added. After addition reaction mixture was stirred at 40° C. for 15 min. at oil bath. After cooling, 50 ml water was added in the reaction mixture. The reaction product was extracted with dichloromethane (30 ml×3). Total solvent obtained was dried over anhydrous sodium sulphate and evaporate the solvent under reduced pressure at 45° C. The yield of pure arteether obtained was 50 mg. The compound was characterised by IR, Mass, 1H NMR.

後処理

  1. additionwas added
  2. additionAfter addition reaction mixture
  3. temperatureAfter cooling
  4. extractionThe reaction product was extracted with dichloromethane (30 ml×3)
  5. customTotal solvent obtained
  6. dry with materialwas dried over anhydrous sodium sulphate
  7. customevaporate the solvent under reduced pressure at 45° C

出典と根拠

ORDレコード
ord-b83677fb7228452cb2cc02b9457830b8
出典データセット
uspto-grants-2002_02
特許番号
US06346631B1

関連ノート

読み込み中…