関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Npc182939 | HCID 456410 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Dihydroartemisinin ethyl ether | HCID 72416 | — |
反応手順
Dihydroartemisinin (50 mg) was dissolved in dry ethanol (3 ml). Add 2 ml of triethylorthoformate and anhydrous AlCl3 (33 mg) was added in the reaction vessel. The reaction mixture was refluxed at 40° C. for 45 min over oil bath with constant stirring. After 45 mins of stirring the reaction product was worked up as mention in the example-3. The pure arteether yielded (45 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06346631B1 |
|---|
| 出典データセット | uspto-grants-2002_02 |
|---|
| ORD ID | ord-2c86ea0e59f7426598e4c5521edcbdaa |
|---|
| 出典メモ | uspto-grants-2002_02 |
|---|
