Water → Dihydroartemisinin ethyl ether

HRID 1699478

反応式

HRID 1699478 の反応式
[CH3:1][C@H:2]1[C@@H:11]2[CH2:12][CH2:13][C:14]3([CH3:18])[O:16][O:17][C@:10]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:19])[O:8][C@@H:9]4[O:15]3)[CH2:4][CH2:3]1.[CH2:21](OC(OCC)OCC)[CH3:22].O>C(O)C>[CH3:21][CH2:22][O:19][C@H:7]1[O:8][C@@H:9]2[O:15][C:14]3([CH3:18])[O:16][O:17][C@@:10]42[C@@H:5]([CH2:4][CH2:3][C@@H:2]([CH3:1])[C@@H:11]4[CH2:12][CH2:13]3)[C@H:6]1[CH3:20]

参加物

5

反応物 3

HCID 962WaterHCID 31214Ethyl orthoformateHCID 456410Npc182939

生成物 1

HCID 72416Dihydroartemisinin ethyl ether

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Dihydroartemisinin (50 mg) was dissolved in 3 ml dry ethanol with stirring the solution for 10 min. at room temperature and add cation exchange resin (Dowex-50, 50 mg) and triethylorthoformate (4 ml) in the solution. The reaction mixture is stirred for 10 hrs at room temperature (30° C.). Water was added in the reaction mixture and filters the cation exchange resin. The reaction product was extracted by dichloromethane. The organic layer was separated, dried over anhydrous sodium sulphate and evaporated under vacuum to yield pure arteether (50 mg).

後処理

  1. stirringThe reaction mixture is stirred for 10 hrs at room temperature (30° C.)
  2. extractionThe reaction product was extracted by dichloromethane
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous sodium sulphate
  5. customevaporated under vacuum

出典と根拠

ORDレコード
ord-27d23df026d04dff94bd070d683976bf
出典データセット
uspto-grants-2002_02
特許番号
US06346631B1

関連ノート

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