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HRID 1699529作成日：2026年10月27日
Potassium Carbonate → 3-{3-[5-Cyano-1-(2,4-dimethoxybenzyl)-3-(3-indolyl)-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-1-indolyl}-propyl methanesulfonate
https://huagongshe.com/reaction/1699529
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,3-Propanediol, 1,3-dimethanesulfonate | HCID 27532 | — |
| 反応物 | 4-Cyano-3-(2,4-dimethoxybenzyl)-5-(3-indolyl)-1-(1-methyl-3-indolyl)-2,3-dihydroimidazol-2-one | HCID 18320729 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-{3-[5-Cyano-1-(2,4-dimethoxybenzyl)-3-(3-indolyl)-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-1-indolyl}-propyl methanesulfonate | HCID 18320759 | — |
反応手順
To a solution 0.15 g (0.298 mmol) of the product from step b) in 2 ml of DMF was 0.40 g (1.72 mmol) of 1,3-propandiol bismethansulfonate and 0.50 g (3.62 mmol) of K2CO3. The mixture was stirred at 70° C. overnight and partitioned between EtOAc and water. The organic phase was washed with water and brine and finally evaporated. The residue was purified by chromatography on silica furnishing 0.11 g (59%) of the sub-title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06346625B1 |
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| 出典データセット | uspto-grants-2002_02 |
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| ORD ID | ord-8490e5a0de73423d845d5d859fab2c15 |
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| 出典メモ | uspto-grants-2002_02 |
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