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2-Chloro-3',4'-dihydroxyacetophenone → 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| 反応物 | 3,4-Dimethoxythiobenzamide | HCID 2758490 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride | HCID 18707355 | 22.2% |
反応手順
In 20 ml of ethanol were suspended 367 mg of 3′,4′-dihydroxy-2-chloroacetophenone and 430 mg of 3,4-dimethoxythiobenzamide. The suspension was refluxed for 3 hours with heating. After cooling, the resulting crystals were collected by filtration, ethanol-washed and dried. The dried material was recrystallized from ethinol to obtain 160 mg of 2-(3,4-dimethoxyphenyl)-4-(3,4-dihydroxyphenyl) thiazole hydrochloride as yellow acicular crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE037556E1 |
| 出典データセット | uspto-grants-2002_02 |
| ORD ID | ord-c25dd21cfed945f88a32716b55257814 |
| 出典メモ | uspto-grants-2002_02 |