4-Methylquinoline → HCID 18681464、化合物

HRID 1699598ノート

反応式

HRID 1699598 の反応式
CC1C=CC(S([O-])(=O)=O)=CC=1.CN1C2C(S/C/1=[CH:22]\[C:23]1[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N+:26]([CH3:33])=[CH:25][CH:24]=1)=CC=CC=2.[Br:34]C[CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40].N1C2C(=CC=CC=2)C(C)=CC=1>O1CCOCC1>[Br-:34].[C:39]([CH2:38][CH2:37][CH2:36][CH2:33][NH+:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]([CH3:22])[CH:24]=[CH:25]1)([OH:41])=[O:40]

参加物

5

反応物 3

HCID 102854-MethylquinolineHCID 163685-Bromovaleric acidHCID 6438345Thiazole orange

生成物 1

HCID 18681464HCID 18681464、化合物収率 70%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

The synthesis of the carboxylic acid derivative of thiazole orange was adapted from published procedures, L. G. S. Brooker, et al., J. Am. Chem. Soc. 64:199-210 (1942); H. S. Rye, et al., Nucl. Acids Res. 20:2803-2812 (1992). 5.7 g (32 mmol) of 5-bromovaleric acid and 1.5 mL (11 mmol) of lepidine were refluxed in 30 mL of distilled dioxane under nitrogen overnight. The reaction mixture was allowed to cool to room temperature and filtered. The precipitate was washed twice with 10 mL of dioxane followed by 50 mL of petroleum ether to yield 2.6 g (70%) of pure 1-(4-Carboxybutyl)-4 -methyl-1,4-dihydro-quinolinium bromide.

後処理

  1. filtrationfiltered
  2. washThe precipitate was washed twice with 10 mL of dioxane

出典と根拠

ORDレコード
ord-7efd199e35314598b888069d4ce7cbb9
出典データセット
uspto-grants-2002_02
特許番号
US06348317B1

反応ノート

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