Glycerol → Bupivacaine (USAN:INN:BAN)

HRID 1699646

反応式

HRID 1699646 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.OCC(CO)O>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 753GlycerolHCID 64737Bupivacaine Hydrochloride

生成物 1

HCID 2474Bupivacaine (USAN:INN:BAN)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A composition suitable for administration in vaginal suppository form la prepared by weighing 2 mg of finely divided polynucleotide medicinal substance into a tared container, adding 10 ml of 0.5% bupivacaine HCl in purified water, to make a total of 10 g, and dissolving or mixing depending on the solubility of the medicinal substance; 70 g of glycerin is added and mixed; 20 g of granular gelatin is then added and the composition heated carefully on a steam bath until the gelatin is dissolved. The melted mixture is poured into chilled molds to yield 20 vaginal suppositories of 6 grams each containing 100 mcg of polynucleotide medicinal substance in admixture with 2.5 mg bupivacaine.

後処理

  1. customA composition suitable for administration in vaginal suppository form la prepared
  2. dissolutiondissolving
  3. additionmixing
  4. additionmixed
  5. addition20 g of granular gelatin is then added
  6. temperaturethe composition heated carefully on a steam bath until the gelatin
  7. dissolutionis dissolved
  8. additionThe melted mixture is poured
  9. temperatureinto chilled molds

出典と根拠

ORDレコード
ord-6611d185663e46d5851fc4871102833d
出典データセット
uspto-grants-2002_02
特許番号
US06348449B1

関連ノート

読み込み中…