Potassium Carbonate → 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine
反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([Br:9])[N:3]=1.[C:10](OCC)(OCC)(OCC)[CH3:11].C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.ClCCl>[Br:9][C:4]1[N:3]=[C:2]2[N:1]=[C:10]([CH3:11])[NH:8][C:7]2=[CH:6][CH:5]=1参加物
6
実験手順
2,3-Diamino-6-bromopyridine (8.16 g) and triethyl orthoacetate (12.0 ml) were mixed in acetic acid (41 ml), and the mixture was refluxed under heating for 29 hr. The mixture was allowed to cool and the solvent was evaporated to give a crude product (10 g). This was dissolved in a sufficient amount of dichloromethane. Anhydrous potassium carbonate and active carbon were added and the mixture was stirred at room temperature. The insoluble matter was filtered off and the solvent was evaporated to give the objective compound (7.59 g) as a pale-yellow powder.
後処理
- temperaturethe mixture was refluxed
- temperatureunder heating for 29 hr
- temperatureto cool
- customthe solvent was evaporated
- customto give a crude product (10 g)
- filtrationThe insoluble matter was filtered off
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-d9c600a22fb84f0dbeeecf82d9a39695
- 出典データセット
- uspto-grants-2002_02
- 特許番号
- US06348474B1
反応ノート
読み込み中…