1-Adamantaneacetic acid → Tricyclo(3.3.1.13,7)decan-1-acetamide

HRID 1700044

反応式

HRID 1700044 の反応式
[C:1]12([CH2:11][C:12]([OH:14])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C([N:17](C(F)(F)C(F)C(F)(F)F)CC)C>N>[C:1]12([CH2:11][C:12]([NH2:17])=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 2

HCID 1232211-Adamantaneacetic acidHCID 136149N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

生成物 1

HCID 86819Tricyclo(3.3.1.13,7)decan-1-acetamide

試薬・触媒・溶媒 1

HCID 222Ammonia溶媒

実験手順

1-Adamantaneacetic acid (11.7 g, 0.06 mole) was dissolved in N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine (13.4 g, 0.06 mole) during which time a highly exothermic reaction occurred. The reaction mixture was allowed to cool to room temperature and cold aqueous ammonia (250 ml) was added slowly. The 1-adamantaneacetamide was isolated as described in example 1 to yield 10.5 g, 90.6 %; mp 173.6-174.0° C. The analytical sample was recrystallized from cyclohexane and sublimed. Anal. Calcd. for C12H19NO: C, 74.63; H, 9.89; N, 7.25. Found: C, 74.36; H, 9.84; N, 7.15.

後処理

  1. customa highly exothermic reaction

出典と根拠

ORDレコード
ord-26bcb2a2a03541149093dcaa1897ca02
出典データセット
uspto-grants-2002_02
特許番号
US06348625B1

関連ノート

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