4-Nitrophenol → 1-TERT-BUTOXY-4-NITROBENZENE

HRID 1700273ノート

反応式

HRID 1700273 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:11]1([CH3:17])[CH:16]=CC=C[CH:12]=1>C(OCC)(=O)C>[C:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)([CH3:17])([CH3:16])[CH3:12]

参加物

4

反応物 2

HCID 9804-NitrophenolHCID 1140Toluene

生成物 1

HCID 109433951-TERT-BUTOXY-4-NITROBENZENE

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

43.79 mmol of N-N-dimethylformamide di-tert-butyl acetal are added, at ambient temperature, to a solution of 10.78 mmol (1.5 g) of 4-nitrophenol in 10 ml of toluene. The reaction mixture is heated at reflux, with vigorous stirring, for 5 hours. The reaction mixture is diluted with ethyl acetate and then washed with water, with saturated aqueous sodium bicarbonate solution and then with 10% aqueous sodium chloride solution. The expected product is obtained by drying the organic phase and then concentrating.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux, with vigorous stirring, for 5 hours
  3. washwashed with water, with saturated aqueous sodium bicarbonate solution

出典と根拠

ORDレコード
ord-e9af818f89a4420d97f95a114b81ae7d
出典データセット
uspto-grants-2002_02
特許番号
US06350759B1

反応ノート

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