2,2-Dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione → 7-Phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dione

HRID 1700505ノート

反応式

HRID 1700505 の反応式
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:14][C:13](=[O:23])[CH:12]=2)C(=O)O1>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:17]1([CH:15]2[CH2:16][C:11]3[NH:10][CH:9]=[CH:5][C:6](=[O:8])[C:12]=3[C:13](=[O:23])[CH2:14]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

3

反応物 1

HCID 183175972,2-Dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione

生成物 1

HCID 183177747-Phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dione収率 72.8%

試薬・触媒・溶媒 1

HCID 7583Diphenyl Ether溶媒

実験手順

A solution of 2,2-dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione (1.0 g) in diphenylether (15 ml) was stirred at 260-280° C. for 30 minutes. Under reduced pressure, the solvent was evaporated, and the resulting crystals were washed with petroleum ether. The crystals were recrystallized from ethanol to give crystals of 7-phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dione (0.51 g).

後処理

  1. customUnder reduced pressure, the solvent was evaporated
  2. washthe resulting crystals were washed with petroleum ether
  3. customThe crystals were recrystallized from ethanol

出典と根拠

ORDレコード
ord-cef436510e1b4e6eadb1c68cb25939c5
出典データセット
uspto-grants-2002_02
特許番号
US06350749B1

反応ノート

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